Endogenous DNA breaks were detected at RNA polymerase II promoters and are likely to contribute to genomic instability
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Molecular background of the T lymphocyte’s Kv1.3 ion channel operation and targeting to the membrane.
The high electric field across the plasma membrane might influence the conformation and behavior of transmembrane proteins that have uneven charge distributions in or near their transmembrane regions. Membrane depolarization of T cells occurs in the tumor microenvironment and in inflamed tissues because of K+ release from necrotic cells and hypoxia affecting the expression of K+ channels.