Lecture - Pharmacy (Biophysics)

Subject: BIOPHYSICS

Year, Semester: 1st year/2nd semester

Number of teaching hours:

  • Lecture: 4
  • Seminar: 13
  • Practical: 15

Subject code: GYBIF06P2-K4

ECTS:  Credit: 4

Department: Department of Biophysics and Cell Biology, Biophysics Division

Semester recommended to take: 1st year 2nd semester.

Semester fot the regular course: 2nd.

Prerequisites of the course: No prerequisites.

Teaching staff: Dr. Zsolt Bacsó and the members of the Department

Educational advisor: Dr. Zsolt Fazekas                                                                               

  • e-mail:
 
1st. week: 8th. week:
Lecture: Introduction to the course. Generation and absorption of X-rays. X-ray contrast materials. Lecture: Diffusion at the molecular level, statistical interpretation. Fick's 1st law. Thermodiffusion. Osmosis
Seminar: S3: Biostatistics. Discrete probability distributions: binomial and Poisson-distribution.
Practical: Practices are performed in subgroups of 4-5 students in a rotary system.
2nd. week: 9th. week:
Lecture: Fluorescence spectroscopy, flurescence techniques.

Lecture: Structure of biological membranes. Membrane transport.
Seminar: S4: Biostatistics. Continuous probability distribution. Normal distribution. Standard normal distribution. Sampling.
Practical: Practices are performed in subgroups of 4-5 students in a rotary system.

3rd. week: 10th. week:
Lecture: Lasers and their biomedical applications. Photodynamic therapy.
Practical: Introduction.
Lecture: Origin of membrane potential Resting potential, action potential, electric excitbility.
Seminar: S5: Biostatistics. Hypothesis testing. Null hypothesis. Statistical significance. z-test.
4th. week: 11th. week:
Lecture: Optical and electron microscopy.
Practical: Practices are performed in subgroups of 4-5 students in a rotary system For subgroup assignment, please see your lab teacher. P1: Determination of diffusion constant P2: Computed tomography Measurement of nuclear radiation P3: Determination of diffusion constant P4: Refractrometry P5: Light microcopy Optical measurements

Lecture: Biophysics of drug delivery. Nanotechnology approaches.
Seminar: S6: Biostatistics. Paired, unpaired t-test, F-test.
Practical: Practical exam

 

5th. week: 12th. week:
Lecture: Ionizing radiations and their interaction with materials. Dosimetry, tissue effects, detection of radiation.

Lecture: Fluid mechanics, blood circulation. Newtonian fluids, viscosity, creams and emulsions.

6th. week: 13th. week

Lecture: Medical imaging (CT, PET, SPECT, MRI)
Seminar: S1: Biostatistics. Probability theory. Set theory. Random events. Conditional probability, marginalization. Independent events.
Practical: Practices are performed in subgroups of 4-5 students in a rotary system.

Lecture: Methods of pharmacological research. Gelelectrophoresis, isoelectric focussing, blotting. Detecting molecular interactions (SPR, FCS, FRET)
Seminar: S: Biostatistics. Consultation.

7th. week: 14th. week

Lecture: Research, diagnostic and therapeutic application of stable and radioactive isotopes. Contrast materials, radipharmacons.
Seminar: S2: Biostatistics. Random variable. Cummulative distribution function, distribution function of random variable. Mean, standard deviation.
Practical: Practices are performed in subgroups of 4-5 students in a rotary system.

Lecture: Methods of pharmacological research. Gelelectrophoresis, isoelectric focussing, blotting. Detecting molecular interactions (SPR, FCS, FRET)
Seminar: S: Biostatistics. Consultation.

 

 

Requirements - Pharmacy (Biophysics)

Compulsory reading:

  • Medical Biophysics (Editors.: S. Damjanovich, J. Fidy, J. Szöllősi, Medicina, Budapest, 2009, ISBN: 978-963-226-127-0)
  • Educational material published on the web page of the Department. (lecture materials, description of lab practicals)
  • Condition for signing the lecture book
    • All labs done (1 spare lab available for make-up)
    • Lab exam attended (no make-up possible)
    • Minimally 5 out of 6 biostatistics seminars attended (no make-up possible)
    • Signing up for the electronic course PHARM-Biophys at the exam.unideb.hu website by the end of week 3 (the site can only be reached from inside the University network)
    • Lectures are officially not compulsory, but heartily recommended

Exams and grading

  • Lab exam (see the actual timetable) –10 points max
  • Final exam in biostatistics (week 13) – 20 points max
  • Exemption test (electronic) in biophysics (week 15), or written exam(electronic) in final exam - 70 points max
  • Total: 100 points. Grades:
    • 50< pass (2)
    • 60< satisfactory (3)
    • 70< good (4)
    • 80< excellent (5)
  • Please note that your work during the semester constitutes a compulsory part of your final score, which cannot be changed during the exam period, so take your studies seriously throughout the semester.

No exam course will be offered for this subject.

Repeaters
Those who have obtained a signature for the subject earlier are exempted from attending the labs and the biostatistics serminars.
Those exempted can chose to keep their scores from last year, or to take the exams together with the rest of the class during the semester. The decision has to be made before the end of the 3rd week of education, and the study advisor at     notified about it.  If you do not write, we automatically assume that you keep last year's score, and no changes to this will be possible. Biostatistics and Lab exemptions, scores, exams, etc are independent from each other.

Frissítés dátuma: 2018.09.07.