Head of the lab
Full Professor
E-mail:
Webpage
Staff
Former members of the group
Research topics
A. Nuclear organization and chromatin structure group - Superhelical and relaxed chromatin domains
Our ambition is to unravel the complex relationships between nucleosome stability and organization of superhelical chromatin loops, and understand the relationships between the organizational principles seen at the nucleosomal and loop levels. We anticipate and investigate observations of therapeutic relevance for chromatin and epigenetic targeting drugs from this vantage point.
Background
Nucleosomal structure is repressive for transcription, hence eukaryotic gene regulation is primarily based on de-repression at the level of the chromatin. It is fine-tuned, among other factors, by histone posttranslational modifications (PTMs), and entails and depends on negative supercoling of the DNA. In line with this global picture, supercoil relaxation elicits a strong, PTM-dependent nucleosome destabilizing effect according to our published and unpublished data. Our previous work has also led us to recognize that DNA superhelicity has a strong and direct impact on the target size and binding affinity of two major classes of anticancer drugs: DNA intercalators and interstrand-crosslinking agents. We have formulated the concept that the intertwined effects of PTMs and regulation of supercoiling are integrated at the level of nucleosome stability what may be an important overall read-out of drug effects.
Summary of recent publications
Representative publications
B. ABC transporters - multidrug resistance
Our current projects
Representative publications
Updated: 2020.04.29.
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